ncRNA name | Neat1 |
ncRNA Category | lncRNA |
ID | NA |
Ensembl | NA |
Synonyms | NA |
Disease name | diabetic retinopathy (DR) |
Species | Rattus norvegicus |
Tissues/Cell_line | retinas; primary rat Müller cells |
Methods | qRT-PCR, Western blot, transfection, RNA immunoprecipitation assay (RIPA), RNA pull-down assay, luciferase reporter assay, flow cytometry |
Expression pattern | down-regulated |
Functional description | Under diabetic conditions, downregulated nuclear paraspeckle assembly transcript 1 decreased the expression of brain-derived neurotrophic factor through elevating miR-497, thereby promoting Müller cells apoptosis and aggravating diabetic retinopathy. |
PubMed ID | 29383970 |
Year | 2018 |
Title | Long non-coding RNA nuclear paraspeckle assembly transcript 1 inhibits the apoptosis of retina Müller cells after diabetic retinopathy through regulating miR-497/brain-derived neurotrophic factor axis. |
Drug-related ncRNA | NO |
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