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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic retinopathy (DR)
ncRNA name Neat1
ncRNA Category lncRNA
ID NA
Ensembl NA
Synonyms NA
Disease name diabetic retinopathy (DR)
Species Rattus norvegicus
Tissues/Cell_line retinas; primary rat Müller cells
Methods qRT-PCR, Western blot, transfection, RNA immunoprecipitation assay (RIPA), RNA pull-down assay, luciferase reporter assay, flow cytometry
Expression pattern down-regulated
Functional description Under diabetic conditions, downregulated nuclear paraspeckle assembly transcript 1 decreased the expression of brain-derived neurotrophic factor through elevating miR-497, thereby promoting Müller cells apoptosis and aggravating diabetic retinopathy.
PubMed ID 29383970
Year 2018
Title Long non-coding RNA nuclear paraspeckle assembly transcript 1 inhibits the apoptosis of retina Müller cells after diabetic retinopathy through regulating miR-497/brain-derived neurotrophic factor axis.
Drug-related ncRNA NO

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